The grant provides two years of continued support to the University of Oregon’s Biology and the Built Environment (BioBE) Center, a pioneering research center founded with Sloan support and dedicated to developing a predictive science of the built environment microbiome through partnerships between architects and biologists. Over the next two years, the BioBE Center, led by microbiologist Jessica Green, will address two primary research questions: what dispersal vectors (e.g., ventilation and human occupancy) significantly influence the microbial profile of the built environment? And what attributes of the built environment (e.g., building materials and interior temperature) shape microbial community composition indoors? Research will be driven by the latest advances in microbiological instrumentation and methodology, including a climate-controlled chamber, microbiome diversity mapping, high throughput sequencing and analysis, and new visualization tools. In addition to conducting basic research and disseminating results through peer-reviewed journals and conferences, the BioBE team will be involved in educating the next generation of built environment microbiologists, training at least one undergraduate student, three graduate students, two postdoctoral fellows, and two architectural research faculty; and developing a new undergraduate course focused on the biology of the built environment.