Funds from this three-year grant support efforts by Jonathan Eisen at the University of California, Davis to provide key intellectual infrastructure support and services to the growing multidisciplinary community of researchers working in indoor microbial ecology. Through the Microbiology of the Built Environment network (microBE.net) Eisen organizes meetings and workshops, provides a hub for resource and information sharing, disseminates results and funding opportunities, aids in the dissemination of data collection and analysis standards and protocols, and helps bridge disciplinary boundaries by connecting researchers in biology, informatics, architecture, and the building sciences. Over the next three years, Eisen will continue the work of microBE.net, providing additional resources to the MoBE community in six thematic areas:  antimicrobials in the BE; nonhumans in the BE; extreme BEs; BE water systems; technical needs for the MoBE field; and general MoBE interests. Activities targeting each theme will include web development, meeting and workshop organization, social media, pilot research projects, creation and curation of open textbooks, development of a community-driven genome sequencing program, writing of scholarly articles on research and tool development, and continued development of the microBEnet blog with further recruitment of MoBE scholars to contribute to the development of modules for MoBE educational activities (e.g., college courses).