The Institute for Research on Innovation and Science (IRIS) provides data and data management services in support of fundamental research on the results of public and private investments in discovery, innovation, and education. Partnering with dozens of research universities, IRIS collects and processes administrative data, links those files with restricted federal microdata, and make the fully documented results available to researchers. Data compiled by IRIS bear on a host of interesting issues about the practice of modern science in a university setting, including return on investment, the productivity of scientific teams, and whether university science labs have spillover effects on local economies. Funds from this grant provide three years of support to IRIS to expand its operations and facilitate use of IRIS data by researchers.