As the expansion of data centers across the United States raises questions about the adequacy of the country’s existing energy supply and infrastructure, many large data centers have begun to consider nuclear power as a potential source of low-carbon electricity. In particular, one proposed solution to meeting the electricity demand growth from data centers is to co-locate this infrastructure with nuclear power generation, whether that be existing nuclear power plants or next-generation nuclear power sources.This grant supports an interdisciplinary research team among scholars based at the University of Michigan, Massachusetts Institute of Technology, and Pittsburgh Technical to assess how data centers and nuclear power generation be co-located. Following an initial landscaping overview, the team will conduct five case studies to identify current and future locations for data center buildout and quantify their associated electricity demand, analyzing technical, economic, legal, regulatory, and safety dimensions. They will also study alternative business models to assess the viability of co-locating data centers and nuclear power generation. They will also study public responses to the co-location of nuclear power and data centers alongside various legal and safety implications of data center and nuclear power co-location, and they will draw on the expertise of an Advisory Committee to inform the case study site selection and research process.